Effect of oxytocin nasal spray on auditory automatic discrimination measured by mismatch negativity

As a treatment for cognitive dysfunction in schizophrenia, oxytocin nasal sprays potentially improve social cognition, facial expression recognition, and sense of smell. Mismatch negativity (MMN) is an event-related potential (ERP) reflecting auditory discrimination while MMN deficits reflect function decline schizophrenia. To determine whether spray affects We measured ERPs healthy subjects during oddball task, both before after administration. Forty were randomly assigned to either the or placebo group. recorded task all 24 international unit (IU) intranasal administration, was compared between two groups. Participants who received had significantly shorter latencies than those placebo. Oxytocin no significant effect on Change amplitude. The shortened that observed administration suggest may promote comparison-decision stage.